北京爱思益普生物科技股份公司

系统药理学,神经退行性疾病模型,疼痛模型

价格:面议 2022-02-03 04:51:01 1725次浏览

PD模型:

大鼠6—OHDA诱导的PD模型

MPTP诱导小鼠模型

A53T synuclein转基因小鼠PD模型

A53T 黑质过表达诱导PD模型(大鼠小鼠)

PFF脑内注射诱导的PD模型(大鼠小鼠)

PFF胃壁注射诱导PD模型(大鼠小鼠)

AD模型

app/ps1转基因模型

5X FAD 转基因模型

Abeta注射诱导AD模型

(1)帕金森病模型—OB(嗅球)立体定位注射AAV-hm-α-syn

给式:立体定位; 注射部位:嗅球; 周期:12周。

The number of times crossing the line and the total distance traveled were lower 6 weeks after the AAV-hm-α-syn injection.

(2)OB(嗅球)立体定位注射AAV-hm-α-syn

A:Presentation of the TH-positive cells in the striatum and SN 12 weeks after injection into the OB.

B&C:The number of TH-positive cells bodies and terminals in the SN-striatum fields is reduced 12 weeks after AAV-hm-α-syn injection.

D&E:DA and DOPAC level in the SN-striatum fields is reduced 12 weeks after AAV-hm-α-syn injection.

(3)OB(嗅球)立体定位注射AAV-hm-α-syn

Overexpression of the Hm-α-syn by the AAV injection

(4)帕金森病模型—MPTP模型及A53T模型

慢性MPTP诱导PD模型(小鼠):

给式:腹腔注射;周期:20天;

给药剂量:Day1-2(10mg/kg),Day3-4(15mg/kg),Day5-6(20mg/kg),Day7-20(25mg/kg)。

Time spend in Beam traversal test is reduced after MPTP injection and in A53T mice.

Mice after MPTP injection and A53T mice fall more easily in Rotarod test.

(5)帕金森病模型—PFF诱导模型

给式:立体定位; 注射部位:纹状体(5μg/side); 周期:12周。

(6)帕金森病模型—6-OHDA诱导模型(大鼠)

给式:立体定位; 注射部位:黑质、纹状体(20μg/8μl,SN/Str各4μl); 周期:2周。

阿扑吗啡-不对称旋转测试:腹腔注射APO-0.5mg/kg

阿朴吗啡诱导旋转行为阳性时,大鼠多以旋转侧前肢为支撑点向损伤对侧的原地转动。动物的旋转行为监测持续30min,超过5次/min,作为PD建模成功的定量指标。

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